Liverpool come into this clash with their age-old rivals in a patch of uncharacteristically poor form.
Arne Slot’s men have lost their last three games in all competitions and will be desperate for three points to maintain their Premier League title challenge.
The visitors moved up to 10th before the international break by beating Sunderland 2-0 at Old Trafford but this is a significant step up in class for Ruben Amorim and his players.